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I miRNA regolano l'espressione genica secondo meccanismi diversi nelle piante e negli animali. Sono stati descritti 9 meccanismi di silenziamento indotti da miRNA [68] :.

Tali meccanismi presentano dinamiche e cinetiche caratteristiche. Le alterazioni del normale pathway di espressione dei miRNA possono avere conseguenze sulla normale fisiologia cellulare e portare a diversi tipi di patologie.

Molti miRNA sono stai associati a varie forme di cancro si fa riferimento a queste molecole come oncomiR. Sembra che il messaggero venga silenziato prima della traduzione.

Ad esempio, uno studio condotto su un campione di cellule affetto da carcinoma polmonare non microcitico ha riscontrato che bassi livelli di miRa sono indice di scarsa sopravvivenza.

Studi condotti sul cuore di topi, nei quali era stata indotta l'inibizione della maturazione dei miRNA, hanno rivelato il ruolo essenziale svolto da queste molecole nello sviluppo dell'organo.

I miRNA potrebbero essere implicati nei processi regolativi dello sviluppo del sistema nervoso. Varie ricerche [97] [98] hanno dimostrato il coinvolgimento di alcuni microRNA in vari processi legati al danno d'organo, come la regolazione della risposta cellulare al danno e la rigenerazione tissutale.

Alcuni studi hanno successivamente valutato in maniera positiva un utilizzo dei miRNA sia a scopo diagnostico [99] che terapeutico [98]. Altri progetti.

Da Wikipedia, l'enciclopedia libera. S52—7, DOI : PMC PMID Cell , vol. Cell Biol. R65, DOI : Today , vol.

Life Sci. Lymphoma , vol. Targets , vol. Psychiatry , vol. URL consultato il 16 luglio To save this word, you'll need to log in.

I'm not worried about minor details. The grant covered only a minor part of the cost. The delay will be minor.

He suffered a minor heart attack. Noun families with children who are still minors The nightclub was shut down for selling alcohol to a minor.

She majored in chemistry with a minor in biology. Smith, Milwaukee Journal Sentinel , "DNR hires Johnson for bear, wolf and cougar position," 12 July The storm is expected to bring 2 to 4 inches 5 to 10 centimeters of rain, with the possibility of minor coastal flooding from New Jersey to Rhode Island as well as flash flooding.

Send us feedback. See more words from the same year Dictionary Entries near minor minny Minoan mino bird minor minorate minoration minor axis.

Accessed 3 Aug. Keep scrolling for more More Definitions for minor minor. Entry 1 of 2 : not very important or valuable : small in number, quantity, or extent : not very serious : not causing much trouble or damage minor.

Entry 1 of 2 1 : not great in size, importance, or seriousness minor details a minor injury 2 : of or relating to a musical scale having the third tone lowered a half step minor.

Entry 1 of 2 : not serious or involving risk to life minor illness a minor operation — compare major minor. Entry 1 of 2 : a person who has not yet reached the age of majority — compare adult , juvenile , major minor.

Please tell us where you read or heard it including the quote, if possible. Test Your Knowledge - and learn some interesting things along the way.

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! And who put it there, anyway?

Literally How to use a word that literally drives some people nuts. Is Singular 'They' a Better Choice? Can you spell these 15 tricky spelling words?

PMID Nach meiner Meinung lassen Sie den Fehler zu. Family Guy Online Deutsch fu individuata una seconda piccola molecola di RNA codificata dal gene lin-7 con azione repressiva sull'mRNA del gene lin In particolare sono stati identificati miRNA contenenti residui di uracile e miRNA contenenti gruppi metilici legati al 2' ossidrile. Emoticons packen.

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I, — Ma niepce, m'amie, depuis que je t'ay cogneu Toutes les traductions de ami. Synonyms for definition Synonyms delineation , depiction , description , picture , portrait , portraiture , portrayal , rendering , sketch , vignette Visit the Thesaurus for More. IV, nouv. XIe s. Please tell us where you read or heard it including the quote, if possible.

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